R. Douglas Wright Biomedical Career Development Award - (Understanding the Mechanisms That Regulate the Onset of Human Labour and Delivery)

Fetal membrane architecture, aging and inflammation in pregnancy and parturition

R Menon, LS Richardson, M Lappas

2019-04-01

Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of ..

Oxidative Stress in Pregnancies Complicated by Diabetes

Martha Lappas, Andrea Leiva, Fabián Pardo, Luis Sobrevía, Alicia Jawerbaum

2014-01-01

The placenta is essential for normal foetal metabolism and growth. However, maternal diabetes is an unfavourable environment for e..

TREM-1 expression is increased in human placentas from severe early-onset preeclamptic pregnancies where it may be involved in syncytialization

R Lim, G Barker, M Lappas

2014-01-01

Preeclampsia, a major cause of maternal and perinatal morbidity and mortality, is thought to be attributable to dysregulation of t..

Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus

KE Boyle, SA Newsom, RC Janssen, M Lappas, JE Friedman

2013-10-01

Context: Insulin resistance and systemic oxidative stress are prominent features of pregnancies complicated by maternal obesity or..

A Novel Role for FOXO3 in Human Labor: Increased Expression in Laboring Myometrium, and Regulation of Proinflammatory and Prolabor Mediators in Pregnant Human Myometrial Cells

R Lim, G Barker, M Lappas

2013-08-23

Preterm birth is the leading factor causing neonatal mortality and morbidity. Inflammation plays a central role in stimulating ute..

2D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue

K Oliva, G Barker, GE Rice, MJ Bailey, M Lappas

2013-08-01

Gestational diabetes mellitus (GDM) is a significant risk factor for the type 2 diabetes epidemic in many populations. Maternal ad..

Apelin is decreased with human preterm and term labor and regulates prolabor mediators in human primary amnion cells

R Lim, G Barker, C Riley, M Lappas

2013-08-01

A critical role of proinflammatory mediators including cytokines, prostaglandins, and extracellular matrix remodeling enzymes in t..

Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia

CL Whitehead, SP Walker, M Lappas, S Tong

2013-08-01

Objective:To determine whether the intrinsic apoptosis pathway is differentially expressed in placenta and maternal blood in sever..

Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium

R Lim, G Barker, CA Wall, M Lappas

2013-07-01

A tenet of contemporary obstetrics is that a significant proportion of preterm births involve bacterial infection. Bacterial endot..

Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer

R Lim, M Lappas, C Riley, N Borregaard, HJ Moller, N Ahmed, GE Rice

2013-01-22

Background: Epithelial ovarian cancer is one of the leading causes of gynaecological cancer morbidity and mortality in women. Earl..

SIRT6 is decreased with preterm labor and regulates key terminal effector pathways of human labor in fetal membranes

R Lim, G Barker, M Lappas

2013-01-01

Preterm birth is a major determinant of neonatal mortality and morbidity, affecting approximately one-third of preterm births as a..

Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells

M Lappas

2012-12-03

A prominent feature of inflammatory diseases is endothelial dysfunction. Factors associated with endothelial dysfunction include p..

Increased chemerin concentrations in fetuses of obese mothers and correlation with maternal insulin sensitivity

G Barker, R Lim, GE Rice, M Lappas

2012-11-01

Objective: The aim of this study was to determine the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i) th..

Omentin-1 Is Decreased in Maternal Plasma, Placenta and Adipose Tissue of Women with Pre-Existing Obesity

G Barker, R Lim, HM Georgiou, M Lappas

2012-08-28

Objective: The aim of this study was to determine (i) the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i..

Increased oxidative stress in human fetal membranes overlying the cervix from term non-labouring and post labour deliveries

M Chai, G Barker, R Menon, M Lappas

2012-08-01

Enzymatic breakdown of the collagen-rich extracellular matrix (ECM) that connects the amnion and chorion layers of the fetal membr..

Nuclear factor-κB mediates placental growth factor induced pro-labour mediators in human placenta

M Lappas

2012-07-01

Prostaglandins, pro-inflammatory cytokines, extracellular matrix remodelling enzymes and nuclear factor-kappa B (NF-κB) are involv..

Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta

M Lappas, S Andrikopoulos, M Permezel

2012-04-01

Appropriate foetal growth and development is dependent on adequate placental glucose uptake. Oxidative stress regulates glucose up..

The effect of pre-existing maternal obesity on the placental proteome: Two-dimensional difference gel electrophoresis coupled with mass spectrometry

K Oliva, G Barker, C Riley, MJ Bailey, M Permezel, GE Rice, M Lappas

2012-04-01

Our aim was to study the protein expression profiles of placenta obtained from lean and obese pregnant women with normal glucose t..

MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin

TJ Kaitu'U-Lino, KR Palmer, CL Whitehead, E Williams, M Lappas, S Tong

2012-03-01

Soluble endoglin is an anti-angiogenic protein that is released from the placenta and contributes to both maternal endothelial dys..

Visfatin regulates the terminal processes of human labour and delivery via activation of the nuclear factor-κB pathway

M Lappas

2012-01-02

The inflammatory process plays a pivotal role during the pathogenesis of human labour, both at term and preterm. Visfatin levels i..

Complement C5A regulates prolabor mediators in human placenta.

M Lappas, TM Woodruff, SM Taylor, M Permezel

2012-01-01

Human preterm and term parturition is associated with inflammatory cascades in the uteroplacental unit. Activation of the compleme..

Decreased expression of complement 3a receptor (C3aR) in human placentas from severe preeclamptic pregnancies

R Lim, M Lappas

2012-01-01

Objectives: The aim of this study was to determine the expression of the anaphylatoxin receptors complement C3a receptor (C3aR) an..

Human labour is associated with decreased cytoplasmic FoxO4

R Lim, C Riley, G Barker, GE Rice, M Lappas

2012-01-01

Forkhead box O (FoxO) proteins function primarily as transcription factors in the nucleus where they bind to their cognate DNA tar..

The role of oxidative stress in the pathophysiology of gestational diabetes mellitus

M Lappas, U Hiden, G Desoye, J Froehlich, SHD Mouzon, A Jawerbaum

2011-12-15

Normal human pregnancy is considered a state of enhanced oxidative stress. In pregnancy, it plays important roles in embryo develo..

The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B 3 derivative, are elicited by FoxO3 in human gestational tissues: Implications for preterm birth

M Lappas, M Permezel

2011-12-01

The inflammatory process plays a pivotal role during the pathogenesis of human labour, both at term and at preterm. Nicotinamide, ..

Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cells

I Ahrens, H Domeij, SU Eisenhardt, D Topcic, M Albrecht, E Leitner, K Viitaniemi, JB Jowett, M Lappas, C Bode, I Haviv, K Peter

2011-09-01

C-reactive protein (CRP) has been linked to the pathogenesis of atherosclerosis. The dissociation of native, pentameric (p)CRP to ..

Lower circulating levels of complement split proteins C3a and C4a in maternal plasma of women with gestational diabetes mellitus

M Lappas

2011-08-01

Aim The aim of this study was to determine the effect of gestational diabetes mellitus on maternal circulating levels of C3a, C4a ..

2D-PAGE of ovarian cancer: Analysis of soluble and insoluble fractions using medium-range immobilized pH gradients

R Lim, M Lappas, N Ahmed, M Permezel, MA Quinn, GE Rice

2011-03-18

Ovarian cancer remains a leading cause of cancer death. A comparative proteomic study was performed on normal ovarian tissue (n=5)..

MAPK and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: Regulation of enzymes involved in the degradation of fetal membranes

M Lappas, C Riley, R Lim, G Barker, GE Rice, R Menon, M Permezel

2011-01-01

Fetal membranes overlying the cervix (i.e. supracervical site, SCS) are characterised by increased extracellular matrix (ECM) degr..

Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression

K Palmer, B Saglam, C Whitehead, O Stock, M Lappas, S Tong

2011-01-01

The genetic deletion of catechol O-methyltransferase (COMT) in mice produces a preeclampsia-like phenotype, with mice exhibiting h..

SIRT1 is a novel regulator of key pathways of human labor

M Lappas, A Mitton, R Lim, G Barker, C Riley, M Permezel

2011-01-01

Human sirtuin (SIRT) 1 and SIRT2, which possess nicotinamide adenosine dinucleotide (NAD+)-dependent deacetylase activity, exhibit..

Expression and localisation of FoxO3 and FoxO4 in human placenta and fetal membranes

M Lappas, R Lim, C Riley, R Menon, M Permezel

2010-12-01

Forkhead box O (FoxO) proteins regulate inflammation, extracellular matrix (ECM) remodelling and apoptosis. We have previously ide..

Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: Gestational diabetes mellitus, intrauterine growth restriction and preeclampsia

SJ Holdsworth-Carson, R Lim, A Mitton, C Whitehead, GE Rice, M Permezel, M Lappas

2010-03-01

Background: Common complications of pregnancy arise in part from dysfunctional placental development, and include gestational diab..

Increased expression of alpha-enolase in cervico-vaginal fluid during labour

NL Dellios, M Lappas, IR Young, HK Palliser, JJ Hirst, K Oliva, M Ayhan, GE Rice

2010-01-01

Objectives: The aim of this study was (i) to characterise differentially expressed proteins in cervico-vaginal fluid (CVF) at the ..

In response to oxidative stress, the expression of inflammatory cytokines and antioxidant enzymes are impaired in placenta, but not adipose tissue, of women with gestational diabetes

M Lappas, A Mittion, M Permezel

2010-01-01

In response to oxidative stress, gestational diabetes mellitus (GDM) placenta releases less 8-isoprostane and tumour necrosis fact..

Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus

M Colomiere, M Permezel, C Riley, G Desoye, M Lappas

2009-09-08

Objective: Studies in adipose tissue and skeletal muscle suggest that impaired insulin action is due to defects in the insulin sig..

Preterm and infection-driven preterm labor: The role of peroxisome proliferator-activated receptors and retinoid X receptor

SJ Holdsworth-Carson, M Permezel, GE Rice, M Lappas

2009-08-26

Approximately 8% of births are complicated by preterm delivery. To improve neonatal outcomes, a greater understanding of the mecha..

Increased expression of ac-FoxO1 protein in prelabor fetal membranes overlying the cervix: Possible role in human fetal membrane rupture

M Lappas, C Riley, GE Rice, M Permezel

2009-07-01

Forkhead box O proteins have critical roles in a number of cellular processes, including apoptosis. Acetylation and phosphorylatio..

Localisation and Expression of FoxO1 Proteins in Human Gestational Tissues

M Lappas, R Lim, C Riley, GE Rice, M Permezel

2009-03-01

In non-gestational tissues, emerging data indicate that the FoxO1 family of Forkhead transcription factors play diverse roles in m..

Transcriptional Regulation of the Processes of Human Labour and Delivery

M Lappas, GE Rice

2009-03-01

Preterm birth is the most important complication contributing to poor pregnancy and neonatal outcome. A critical issue that must b..

Peroxisome Proliferator-activated Receptors and Retinoid X Receptor-alpha in Term Human Gestational Tissues: Tissue Specific and Labour-associated Changes

SJ Holdsworth-Carson, M Permezel, C Riley, GE Rice, M Lappas

2009-02-01

Peroxisome proliferator-activated receptors (PPARs) and their transcriptional partner retinoid X receptor (RXR) are involved in tr..

Pre-labour Fetal Membranes Overlying the Cervix Display Alterations in Inflammation and NF-κB Signalling Pathways

M Lappas, TL Odumetse, C Riley, NG Reti, SJ Holdsworth-Carson, GE Rice, M Permezel

2008-12-01

To generate new insights into the process of fetal membrane rupture, we have developed a technique whereby fetal membranes overlyi..

Mitogen-Activated Protein Kinase Proteins Regulate LPS-Stimulated Release of Pro-inflammatory Cytokines and Prostaglandins from Human Gestational Tissues

M Lappas, M Permezel, GE Rice

2007-08-01

The role of pro-inflammatory cytokines and prostaglandins in human labour is well established. Many of the mRNAs stabilised by the..

Antiinflammatory effects of the cyclopentenone isoprostane 15-A2-IsoP in human gestational tissues

M Lappas, M Permezel, SJ Holdsworth, G Zanoni, A Porta, GE Rice

2007-06-15

Proinflammatory prostaglandins and cytokines are involved in the initiation of human labor and delivery. Although cyclopentenone p..